Associate Scientist II

Company: Aditi Consulting
Location: Lexington
Posted on: June 24, 2025

Job Description:

Payrate: $44.72 - $44.72/hr. Summary: The company is seeking a highly motivated Associate Scientist II to join the Oligonucleotide Chemistry Team. The candidate will be responsible for analysis and purification of oligonucleotides. This position will support therapeutic programs in multiple disease areas and will contribute to the development of novel nucleic acid conjugate platforms. Prior experience in LCMS method development and oligonucleotide purification and characterization is desired. This position reports to the Director, Oligonucleotide Chemistry as an individual contributor. Daily interaction with other peers in oligo synthesis, medicinal chemistry and biology teams in support of early phase product pipeline. Responsibilities: Primary responsibility to provide analytical lab support for Company’s Oligonucleotide early phase pipeline Development of robust LC/MS, IPRP and SAX analytical methods for analysis and purification of highly modified oligonucleotide drug substances. Prepare analytical samples, analyze and process data, primarily by UPLC, LC-MS Operate, maintain and troubleshoot lab instruments Conduct and help design unique experiments to help in characterization of highly modified oligonucleotides and sgRNA Keep accurate records of the experiments and summarize the results in well communicated presentations or written reports Purification, deprotection, annealing and lyophilization of oligonucleotides to support all disease programs Oligonucleotide synthesis Possess excellent written and verbal communication skills Conduct laboratory work in an efficient manner that ensures a safe working environment Qualifications: MS or BS with 3 years of industrial experience Strong knowledge of mass spectrometry and purification techniques Experience with waters LC/MS instruments preferred Experience with purification and LC/MS analysis of sgRNA highly preferred Experience with analytical techniques e.g. RP-UPLC, SAX-HPLC, LC-MS and data interpretation Strong background in the analytical development of methods for the analysis of oligonucleotide therapeutics Experience with IP-RP-UHPLC and AX-HPLC analytical techniques using Ag-ilent, Waters and/or Thermo UHPLC’s and associated software In depth knowledge of GLP/GMP’s in a pharmaceutical environment The successful candidate must possess excellent writing and communication skills and a demonstrated ability to work independently and with cross-functional teams Desired Skills: LC/MS experience /oligo method development Mass Spec Maintenance and trouble shooting Oligonucleotide Purification Pay Transparency: The typical base pay for this role across the U.S. is: $44.72 - $44.72 /hr. Final offer amounts, within the base pay set forth above, are determined by factors including your relevant skills, education and experience and the benefits package you select. Full-time employees are eligible to select from different benefits packages. Packages may include medical, dental, and vision benefits, 10 paid days off, 401(k) plan participation, commuter benefits and life and disability insurance. For information about our collection, use, and disclosure of applicant's personal information as well as applicants' rights over their personal information, please see our Privacy Policy (https://www.aditiconsulting.com/privacy-policy). Aditi Consulting LLC uses AI technology to engage candidates during the sourcing process. AI technology is used to gather data only and does not replace human-based decision making in employment decisions. By applying for this position, you agree to Aditi’s use of AI technology, including calls from an AI Voice Recruiter.

Keywords: Aditi Consulting, Pawtucket , Associate Scientist II, Science, Research & Development , Lexington, Rhode Island